“The (in)stability of recombination rates”
3 year PhD position – starting as soon as possible
A PhD position is available in the laboratory of Dr. Bart Nieuwenhuis at the division of Evolutionary Biology, Ludwig-Maximilians-University of Munich, Germany. My lab uses the fission yeast Schizosaccharomyces pombe to investigate the evolution of sexes and local adaptation, which both depend on the rise and maintenance of beneficial allele combinations. The rate of recombination between loci with such alleles and along the genome in general greatly affect the course of evolution, however, little is known about the rise of recombination landscapes and their stability.
I seek a self-motivated candidate to conduct studies on the evolution of recombination rates using a combination of phenotyping, genomics, and experimental evolution approaches. Specifically, you will investigate natural variation and heritability of recombination rates between individuals and along the genome. Additionally, you’ll study the evolvability of local and global recombination rates using an experimental evolution approach, followed by genomic and functional genetic analyses in collaboration with Dr Alexander Lorenz at the University of Aberdeen, UK. Your results will help understand how recombination landscapes are shaped and can evolve, and which mechanisms might generate variation in recombination rates.
I welcome all applicants with a background in evolutionary biology, molecular biology, genetics or related subjects that have completed a Master course or equivalent. Candidates with experience in using yeast as a model system are especially encouraged to apply. This work takes a multidisciplinary approach, combining methods in genomics, molecular genetics, and microbial experimental evolution; the ideal candidate is interested and committed to working both in the wet lab and on the computer.
At the division of Evolutionary Biology, we take an integrative approach to the study of evolutionary processes (http://www.evol.bio.lmu.de/), and apply a wide range of methodologies that include evolutionary theory, population genetics modelling, genomic approaches, experimental evolution and functional characterization. The working language in our lab and division is English. Knowledge in German is not required, but students are encouraged to take free German classes on campus if they want. The student will also spend some time at the University of Aberdeen (UK), in Dr Alexander Lorenz’s research group.
This position is funded for 3 three years by a grant from the German Research Foundation DFG.
How to apply?
Informal inquiries should be directed to Dr. Bart Nieuwenhuis (firstname.lastname@example.org). Applications, including a CV, a motivation letter, and names and contact information of at least two referees should be sent as a single pdf file before 16 February 2020 to the same address using the subject header “Recombination Rates PhD”.
There are currently no vacancies for post-doc positions in the lab, but researchers at any stage of their career are encouraged to contact me to discuss opportunities. Some possibilities are to write funding applications post-doctoral fellowships such as: